Aye Propeller,
Used to run 5/8 x 3/8 (530) Renold's best that is standard pitch, on the Duke 450, with a 12 tooth gearbox sprocket and a 32 tooth rear sprocket, and found that I had reduced it to knicker elastic by 5,000 miles. Going up to a 13 tooth sprocket on the gearbox and 35 tooth rear gave about an extra 1,000 miles and similar gearing. However, there was a time in the mid to late '90's when 450 13T 530 gearbox sprockets were not available and the gearbox sprocket from a Honda CD175 with 17 teeth was a direct fit + a spacer to space the sprocket out from the gearbox. This is a 428 chain and with a 45 tooth rear sprocket readily available for the 250 - 350 Ducati racers, this provided the desired ratio and good mileage, 6,000 - 7,000miles before the knicker elastic syndrome returned.
Lack of lubrication and 'thumping' in a high gear, I believe, wreck havoc with a chain and maybe the increased mass of the individual components in the 530 chain could contribute to it's greater longevity on the bigger sprockets. I also know that Ducati singles taken out to 490cc for racing, run 428 chain very succesfully, without increased wear on the chain or sprockets. Good lubrication and not lugging the motor make all the difference.
Happy cantering, Bill