I've used semi synthetic for some time in a couple of big singles. Yes, the first time I put it into gear after it's sat for a while, I tend to get a "clunk", but then that's common for many bikes in my experience (hence why I'm particular about holding on the front brake while engaging gear on an unfamiliar bike :-0 !!) Thereafter it's generally sweet as you like.
Personally, and only in my experience, Semi synthetic oils have been good in bikes I've run, no problems with wear showing on components after disassembly and long service life. I'll be sticking with them. (Incidentally, alhough I've used a few I'm currently using silkoline in the MuZ).
You could try an oil change and see how it goes, or engage and release the clutch a couple of times before attempting to engage gear, or warm up for a few minutes before engaging gear and see how each approach helps/doesn't help with the prob.
Let us know how it works out, always interesting!!
Cheers,
Smudge