Yes indeed, i ran a 42mm Dellorto (with accelerator pump) on a handmade two into one manifold.....and it worked very well, on my #1 srx6...which at the time was 620 cc....only reason i'm not using it now is because i won a pair of 34 mm dellorto's on ebay and thought i'd give them a try for a year.
lots of things you need to be aware of when going down this route.....
Obviously you will need a one into two manifold.....as short as possible
the height of the dellorto required that the tap assembly on the tank had to be removed (the hole plated over) and the tank area immediately above the carb had to be bashed in with a leather mallet to allow sufficient clearance.
new petrol feed outlets need welding into the tank (mine are either side at the lowest ends of the tank)
if you use the standard fuel tap, then you will need to run the tap on 'prime' unless your carb or manifold has a vacuum take off.
the breather on the top of the oil tank had to be moved to one side, and your throttle and choke cables need modifying
your throttle and choke cables will need modifying to match the carb (single throttle cable)
probably other things i've forgotten....but thats enough to be going on with :-)